Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors

J Nucl Med. 1979 Jul;20(7):753-60.


5-thio-D-glucose (5-TDG) exerts profound effects on rapidly metabolizing tissues. We have used liquid scintillation counting to study the tissue distribution and pharmacokinetics of S-35-labeled 5-TDG in hamster models of pancreatic tumors. In the normal hamster, initial uptake of S-35 activity into kidney, liver, and blood was high, but rapidly decreased with time. The pancreatic uptake (% dose/g) never exceeded 0.75%. This level occurred only at the earliest times after administration. Uptake in all three tumor models exceeded that in pancreatic tissue within 15 min of injection. The highest tumor-to-pancreas ratio was seen in the duct-tumor model, which also exhibited the most favorable tumor-to-tissue ratio when compared with kidney, liver and muscle. Favorable ratios were most pronounced at 6 and 24 hr after injection. These studies provide impetus for the use of 5-TDG as a model compound for the synthesis of potentially useful agents for clinical detection of pancreatic tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenoma, Islet Cell / metabolism
  • Animals
  • Cricetinae
  • Glucose / analogs & derivatives*
  • Glucose / metabolism
  • Kinetics
  • Male
  • Mesocricetus
  • Neoplasms, Experimental / metabolism
  • Pancreatic Ducts
  • Pancreatic Neoplasms / metabolism*
  • Sulfur Radioisotopes*
  • Tissue Distribution


  • Sulfur Radioisotopes
  • 5-thio-D-glucose
  • Glucose