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Review
. 2012 Dec;53 Suppl 9(Suppl 9):32-40.
doi: 10.1111/epi.12033.

Dendritic Ion Channelopathy in Acquired Epilepsy

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Free PMC article
Review

Dendritic Ion Channelopathy in Acquired Epilepsy

Nicholas P Poolos et al. Epilepsia. .
Free PMC article

Abstract

Ion channel dysfunction or "channelopathy" is a proven cause of epilepsy in the relatively uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of acquired channelopathy in experimental animal models of epilepsy following brain injury have also been demonstrated. Our understanding of channelopathy has grown due to advances in electrophysiology techniques that have allowed the study of ion channels in the dendrites of pyramidal neurons in cortex and hippocampus. The apical dendrites of pyramidal neurons comprise the vast majority of neuronal surface membrane area, and thus the majority of the neuronal ion channel population. Investigation of dendritic ion channels has demonstrated remarkable plasticity in ion channel localization and biophysical properties in epilepsy, many of which produce hyperexcitability and may contribute to the development and maintenance of the epileptic state. Herein we review recent advances in dendritic physiology and cell biology, and their relevance to epilepsy.

Conflict of interest statement

Disclosures

The authors have no conflicts of interest to disclose.

We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Figures

Figure 1
Figure 1
Two-photon micrograph of a CA1 hippocampal pyramidal neuron showing the profusion of apical and basilar dendrites emanating from the cell soma. Micrograph courtesy of Raymond Chitwood, PhD.

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