Cleaning up: ER-associated degradation to the rescue

Cell. 2012 Dec 7;151(6):1163-7. doi: 10.1016/j.cell.2012.11.012.

Abstract

All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / physiology*
  • Endoplasmic Reticulum-Associated Degradation*
  • Humans
  • Protein Folding
  • Protein Transport
  • Proteins / metabolism*
  • Secretory Pathway*

Substances

  • Proteins