Effects of ceftriaxone on ischemia/reperfusion injury in rat brain

J Clin Neurosci. 2013 Mar;20(3):457-61. doi: 10.1016/j.jocn.2012.05.030. Epub 2012 Dec 7.

Abstract

The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n=10), I/R group (n=10) and I/R-ceftriaxone group (n=10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p<0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p<0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue.

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Brain Ischemia / drug therapy*
  • Ceftriaxone / pharmacology*
  • Male
  • Neuroprotective Agents / pharmacology*
  • Rats
  • Rats, Wistar
  • Reperfusion Injury / drug therapy*

Substances

  • Antioxidants
  • Neuroprotective Agents
  • Ceftriaxone