The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

Biochim Biophys Acta. 2013 Mar;1827(3):401-10. doi: 10.1016/j.bbabio.2012.11.014. Epub 2012 Dec 7.


Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non-standard, tissue-specific component of mammalian mitochondria. But despite its very simple structure, mGPDH is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle it functions at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism. In this review we summarize the present knowledge on the structure and regulation of mGPDH and discuss its metabolic functions, reactive oxygen species production and tissue and organ specific roles in mammalian mitochondria at physiological and pathological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • Fatty Acids / metabolism
  • Glycerolphosphate Dehydrogenase / genetics
  • Glycerolphosphate Dehydrogenase / physiology*
  • Glycolysis
  • Humans
  • Mitochondria / enzymology*
  • Organ Specificity
  • Oxidative Phosphorylation
  • Reactive Oxygen Species / metabolism
  • Succinate Dehydrogenase / metabolism


  • Fatty Acids
  • Reactive Oxygen Species
  • Glycerolphosphate Dehydrogenase
  • Succinate Dehydrogenase