Pressure ulcer prevention is an important aspect of nursing home care. A 20-week, unblinded, randomized, controlled trial was conducted to compare the rate of nursing home-acquired pressure ulcers and adverse events between residents managed using: 1) a silk-like textile for bedding paired with high-absorbency adult incontinence briefs or 2) usual-care, plain-weave cotton/polyester bed sheets and adult incontinence briefs. All residents with an expected length of stay 30 days or more who agreed to participate were enrolled in the study and assessed daily. A total of 46 residents (all men) was enrolled; 26 (median age 72.7 years, range 54 to 95 years) in the intervention group and 20 (median age 69.5 years, range 51 to 91 years) in the usual care group. At baseline, there were no significant differences in resident demographic variables, including Braden Scale risk scores. Fewer pressure ulcers developed in the intervention (six; average follow up 75.6 days/person) than in the standard care group (20; average follow up 95.6 days/person) (hazard ratio = 0.31, 95% confidence interval 0.12, 0.78) and the number of new non-Stage I ulcers was significantly lower in the intervention group (HR = .23, 95% CI .078, .69, P = 0.0084). The number of adverse events did not differ significantly between the two groups. Additional research is warranted on use of products with the silk-like fabric, alone or in combination with highabsorbencybriefs, in larger groups and different populations.