The development of independent foci in epileptic patients

Arch Neurol. 1990 Apr;47(4):406-11. doi: 10.1001/archneur.1990.00530040048018.


The electroencephalograms of 309 unselected epileptic patients were reexamined to ascertain the incidence of independent secondary discharges. In 41 patients (13%), a simple one-sided focus, without evidence of independent secondary discharges, was found (group 1); in 33 patients (11%), an epileptic focus with certain evidence of independent secondary discharges was found (group 2). These two groups were compared with respect to multiple variables (eg, seizure type, time course of the epileptic illness, site of foci, medication, neurological status), and significant differences between the two groups were obtained (eg, with respect to frequency of seizures, duration of seizures, number of anticonvulsive drugs being taken, and in other respects). Our findings are compared with earlier work, and it is concluded that they do not support the conventional models of secondary epileptogenesis.

MeSH terms

  • Carbamazepine / therapeutic use
  • Electroencephalography*
  • Epilepsy / drug therapy
  • Epilepsy / physiopathology*
  • Humans
  • Nervous System / physiopathology
  • Time Factors


  • Carbamazepine