Single photon emission computed tomography/computed tomography in the evaluation of neuroendocrine tumours: a review of the literature

Nucl Med Commun. 2013 Feb;34(2):98-107. doi: 10.1097/MNM.0b013e32835bd59d.


The scintigraphic investigation of neuroendocrine tumours such as carcinoids has depended on standard techniques such as I-metaiodobenzylguanidine and In-pentetreotide imaging. More recently, the use of PET techniques such as Ga-DOTATATE has been advocated. An alternative improved modality is high-quality single photon emission computed tomography/computed tomography (SPECT/CT), which has the advantages of better sensitivity and specificity and has shown improved localization in up to 60% of cases. These advantages are especially true for pancreatic and lymph node lesions. Overall, SPECT/CT can result in a change in clinical management in 25% of patients. Although it is possible to combine SPECT and CT performed at different time points, there is better anatomical localization and improved reporter confidence when SPECT and CT are performed simultaneously.

Publication types

  • Review

MeSH terms

  • 3-Iodobenzylguanidine
  • Humans
  • Iodine Radioisotopes
  • Multimodal Imaging / methods*
  • Neuroendocrine Tumors / diagnostic imaging*
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / radiotherapy
  • Positron-Emission Tomography*
  • Somatostatin / analogs & derivatives
  • Tomography, X-Ray Computed*


  • Iodine Radioisotopes
  • 3-Iodobenzylguanidine
  • Somatostatin