Mechanisms of implantation: strategies for successful pregnancy

Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012.


Physiological and molecular processes initiated during implantation for pregnancy success are complex but highly organized. This review primarily highlights adverse ripple effects arising from defects during the peri-implantation period that perpetuate throughout pregnancy. These defects are reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic growth, manifesting in preeclampsia, miscarriages and/or preterm birth. Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Decidua / physiology*
  • Embryo Implantation / physiology*
  • Female
  • Humans
  • Mice
  • Models, Biological*
  • Placentation / physiology*
  • Pregnancy
  • Pregnancy Complications / physiopathology*
  • Pregnancy Outcome
  • Signal Transduction / physiology*
  • Uterus / physiology*