How Many Sputum Culture Results Do We Need to Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients During Treatment?

J Clin Microbiol. 2013 Feb;51(2):644-6. doi: 10.1128/JCM.02837-12. Epub 2012 Dec 5.

Abstract

Discharge of a hospital patient after a single negative sputum culture may save money when treating multidrug-resistant tuberculosis. However, after initial sputum conversion in 336 South Africans, 11.6% and 5.4% reconverted after 1 and 2 months, respectively. These findings endorse the WHO definitions of 2 negative cultures taken ≥ 30 days apart after sputum culture conversion.

MeSH terms

  • Adult
  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium tuberculosis* / drug effects
  • Mycobacterium tuberculosis* / growth & development
  • Mycobacterium tuberculosis* / isolation & purification
  • Sputum / microbiology*
  • Time Factors
  • Tuberculosis, Multidrug-Resistant / diagnosis*
  • Tuberculosis, Multidrug-Resistant / drug therapy

Substances

  • Antitubercular Agents