Two experiments were conducted to test the feeding value of fermented cottonseed meal (FCSM) in broilers. In experiment 1, 480 1-day-old male yellow-feathered broilers were allocated into 4 dietary treatments with 6 replicates (20 birds per replicate) to examine the effects of FCSM on the growth response of chickens. Experimental feeding was performed for 6 weeks in two phases (starter, days 0 to 21; finisher, days 22 to 42). FCSM was used at 0, 40, 80, and 120 g/kg levels to replace soybean meal in the basal diet. The dietary inclusion of 40 and 80 g/kg FCSM increased (quadratic (Q): p<0.01) the body weight gain of broilers in the starter and in the overall feeding periods. Experiment 2 determined the effect of FCSM on the cecal microbial populations, intestinal morphology, and digestive enzyme activity of broilers. The number of lactobacilli in the cecal digesta increased at day 21 (p<0.01) and day 42 (linear (L): p=0.01). Coliform bacteria counts decreased (L: p<0.05) with the increasing inclusion of FCSM at day 21. The inclusion of FCSM increased (L-Q: p<0.05) villus height in the duodenum and linearly elevated (p<0.05) villus height and the villus height to crypt depth ratio in the jejunum at day 21. Similar improvement (L: p<0.05) was noted in jejunal villus height at day 42. The inclusion of FCSM improved (p<0.05) the activities of amylase and protease at day 21, as well as protease at day 42. In conclusion, the appropriate inclusion of FCSM improves growth, cecal microflora, intestinal morphology, and digestive enzyme activity in yellow-feathered broilers.