Paraneoplastic neuromuscular disorders

Muscle Nerve. 2012 Dec;46(6):841-50. doi: 10.1002/mus.23502.


Introduction: Paraneoplastic neurological disorders are rare autoimmune conditions that can affect any part of the nervous system, including the peripheral nervous system. These disorders are associated with certain types of cancer, and the peripheral nervous system dysfunction often precedes the symptoms from the cancer itself.

Methods: This investigation was undertaken as a topic review.

Conclusions: Learning to recognize paraneoplastic neuromuscular disorders, the associated antibodies and their implications, and the appropriate screening modalities can, in some cases, lead to an earlier diagnosis of cancer. Eliminating the cancer, if present, and immunomodulation can potentially improve the symptoms and clinical outcome.

Publication types

  • Review

MeSH terms

  • Humans
  • Neuromuscular Diseases / complications*
  • Neuromuscular Diseases / diagnosis
  • Neuromuscular Diseases / therapy
  • Paraneoplastic Syndromes, Nervous System / complications*
  • Paraneoplastic Syndromes, Nervous System / diagnosis
  • Paraneoplastic Syndromes, Nervous System / therapy