IL28B Single-Nucleotide Polymorphism rs12979860 Is Associated With Spontaneous HIV Control in White Subjects

J Infect Dis. 2013 Feb 15;207(4):651-5. doi: 10.1093/infdis/jis717. Epub 2012 Dec 7.

Abstract

The single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene has been associated with the spontaneous clearance of hepatitis C virus. We sought to determine whether this SNP could be associated with the spontaneous control of human immunodeficiency virus (HIV) infection. We studied the prevalence of the IL28B CC genotype among 53 white HIV controllers, compared with the prevalence among 389 HIV-infected noncontrollers. We found that the IL28B CC genotype was independently associated with spontaneous HIV control (odds ratio [OR], 2.669; P = .017), as were female sex (OR, 7.077; P ≤ .001) and the presence of HLA-B57 and/or B27 (OR, 3.080; P = .017). This result supports the idea that common host mechanisms are involved in the spontaneous control of these 2 chronic infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • European Continental Ancestry Group / genetics*
  • Female
  • Genotype
  • HIV Infections / genetics*
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HLA-B Antigens / genetics
  • Hepatitis C, Chronic / genetics
  • Hepatitis C, Chronic / immunology
  • Hepatitis C, Chronic / virology
  • Humans
  • Interferons
  • Interleukins / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Viral Load

Substances

  • HLA-B Antigens
  • HLA-B57 antigen
  • IFNL3 protein, human
  • Interleukins
  • Interferons