Trichorhinophalangeal syndrome type 1: A case report with literature review

J Nat Sci Biol Med. 2012 Jul;3(2):209-11. doi: 10.4103/0976-9668.101936.

Abstract

Trichorhinophalangeal syndrome is a very rare genetic disorder, where damage and mutation to the number 8 chromosome affects sufferers in numerous ways. The syndrome has three types, all characterized by abnormally short stature, sparse hair, short deformed fingers with cone-shaped epiphyses visible in radiographs. Type I is the most common. Type II is characterized by the development of multiple bony exostoses and frequently, mental disability. Type III is a more severe form of type I and is associated with short stature. This report presents a 28-year-old man who had the characteristic features of type I with the presence of multiple erupted supernumerary teeth with normal mentation and karyotyping with high resolution G banding displayed normal chromosomal complements.

Keywords: Cone-shaped epiphyses; Herthoge's sign; chromosome 8q 24.12; supernumerary teeth; trichorhinophalangeal syndrome type 1.

Publication types

  • Case Reports