A case of capecitabine-induced sarcoidosis

Tuberc Respir Dis (Seoul). 2012 Mar;72(3):318-22. doi: 10.4046/trd.2012.72.3.318. Epub 2012 Mar 31.


Sarcoidosis is an inflammatory disease involving multiple-organs with an unknown cause. The new onset of sarcoidosis associated with therapeutic agents has been observed in 3 clinical settings; tumor necrosis factor antagonists in autoimmune rheumatologic diseases, interferon alpha with or without ribavirin in patients with chronic hepatitis C or melanoma, and antineoplastic agent-associated sarcoidosis in patients with hematologic malignancies. Here, we report a female patient who developed sarcoidosis after capecitabine treatment as an adjuvant chemotherapy for sigmoid colon cancer. To our knowledge, this is the first report of a capecitabine-induced sarcoidosis.

Keywords: Capecitabine; Sarcoidosis; Sigmoid Neoplasms.