The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats

Brain Res. 1990 Feb 26;510(1):171-4. doi: 10.1016/0006-8993(90)90748-z.


Delta sleep-inducing peptide (DSIP) and P-DSIP, phosphorylated analogue, were found to have enhancing effects on hypothermia induced by i.p. injection of apomorphine (2 mg/kg), a dopamine agonist. Further, the action of P-DSIP appeared and diminished more quickly than that of DSIP. A minimal effective dose of these peptides was 10 ng and the dose-response relationship exhibited an inverted bell-shape with a maximal effective dose of 1 microgram. By the pretreatment of anti-DSIP the enhancing effect of DSIP but not P-DSIP, was totally abolished and the action of both peptides was antagonized by haloperidol. These findings suggest that DSIP and P-DSIP have a close relation to the dopaminergic system on the thermoregulatory mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apomorphine / pharmacology*
  • Delta Sleep-Inducing Peptide / pharmacology*
  • Dose-Response Relationship, Drug
  • Hypothermia / chemically induced*
  • Hypothermia / metabolism
  • Male
  • Phosphorylation
  • Rats
  • Rats, Inbred Strains


  • Delta Sleep-Inducing Peptide
  • Apomorphine