Genomic architecture of heritability and genetic correlations for intramuscular and back fat contents in Duroc pigs

J Anim Sci. 2013 Feb;91(2):623-32. doi: 10.2527/jas.2012-5270. Epub 2012 Dec 10.

Abstract

Genetic parameters such as heritability and correlations of fat traits in a Duroc population were dissected using molecular markers. The heritabilities of intramuscular fat in 2 muscles, the gluteus medius and LM, and back fat were 0.54, 0.48, and 0.23, respectively. The genetic correlations were well estimated with standardized SNP effects, being 0.65 between intramuscular fat traits and ∼0.37 between any intramuscular fat trait and back fat. Genetic correlations were overestimated when ignoring molecular information. Twelve chromosomes showed additive genetic variance for intramuscular fat compared with 8 for back fat. Population structure was accommodated using 4 different models. The number of significant, P < 5 × 10(-5) (suggestive, P < 2 × 10(-3)), SNP varied across models and ranged from 0 to 4 (2 to 261) for intramuscular fat in the gluteus medius, from 0 to 57 (9 to 564) for intramuscular fat in the LM, and from 3 to 4 (22 to 168) for back fat. Several SNP showed significant deviations from an additive mode of action. Only 2 SNP significantly affected 2 traits simultaneously.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / physiology*
  • Animals
  • Body Composition / genetics*
  • Body Composition / physiology
  • Gene Regulatory Networks
  • Genome-Wide Association Study / veterinary
  • Genomics
  • Genotype
  • Male
  • Models, Genetic
  • Muscle, Skeletal
  • Swine / genetics*
  • Swine / physiology