[Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery]

Zh Vopr Neirokhir Im N N Burdenko. 2012;76(5):3-11; discussion 12.
[Article in Russian]


Absence of well-defined borders of the glial tumor due to their infiltrative growth is one of the main issues in neurosurgery. A number of methods for intraoperative visualization are available today. The fluorescent metabolic navigation with 5-aminolevulinic acid (5-ALA) combined with quantitative laser spectroscopy is one of the latest technique. In our series of 99 consecutive patients with brain gliomas (WHO Grade I-IV) we found that visible fluorescence was observed in 68% of cases. Additional use of the laser spectroscopy could increase method sensitivity up to 74% due to accumulation of the protoporphyrine IX in nonfluorescense tumors. It was shown that there are some differences in quantitative fluorescence not only within same tumor (glioblastoma) but also in-between low- and high-grade gliomas. Intraoperative fluorescence and laser spectroscopy are effective and very helpful methods of intraoperative imaging in of intrinsic brain tumor surgery.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aminolevulinic Acid / administration & dosage*
  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / surgery
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurosurgical Procedures / instrumentation*
  • Neurosurgical Procedures / methods*
  • Photosensitizing Agents / administration & dosage*
  • Protoporphyrins / administration & dosage*
  • Spectrometry, Fluorescence


  • Photosensitizing Agents
  • Protoporphyrins
  • Aminolevulinic Acid
  • protoporphyrin IX