Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats

Addict Biol. 2014 May;19(3):338-42. doi: 10.1111/adb.12015. Epub 2012 Dec 12.


In rats, reexposure to heroin-paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine-, cue- and context-induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context-induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma-aminobutyric acid agonists muscimol + baclofen decreased context-induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context-induced relapse across drug classes.

Keywords: Conditioned cues; drug environment; heroin self-administration; hippocampus; muscimol + baclofen; reinstatement; relapse.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Baclofen / pharmacology
  • Cues
  • Drug-Seeking Behavior / drug effects
  • Extinction, Psychological / drug effects
  • GABA-A Receptor Agonists / pharmacology
  • Heroin / pharmacology
  • Heroin Dependence / physiopathology*
  • Hippocampus / drug effects
  • Hippocampus / physiopathology*
  • Muscimol / pharmacology
  • Narcotics / pharmacology
  • Rats
  • Recurrence
  • Self Administration


  • GABA-A Receptor Agonists
  • Narcotics
  • Muscimol
  • Heroin
  • Baclofen