Molecular understanding of the slit diaphragm

Pediatr Nephrol. 2013 Oct;28(10):1957-62. doi: 10.1007/s00467-012-2375-6. Epub 2012 Dec 12.


Glomerular filtration has always attracted the interest of nephrologists and renal researchers alike. Although several key questions on the structure and function of the kidney filter may have been answered within the last 40 years of intense research, there still remain crucial questions to be solved. The following article attempts to give a brief overview of recent developments in glomerular research highlighting particular advances in our understanding of the slit diaphragm.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Glomerular Filtration Barrier / metabolism*
  • Glomerular Filtration Barrier / pathology
  • Glomerular Filtration Barrier / physiopathology
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Diseases / metabolism*
  • Kidney Diseases / pathology
  • Kidney Diseases / physiopathology
  • Permeability
  • Podocytes / metabolism*
  • Podocytes / pathology
  • Signal Transduction