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. 2012 Dec 7;3:163.
doi: 10.3389/fneur.2012.00163. eCollection 2012.

Psychopathology in Pediatric Epilepsy: Role of Antiepileptic Drugs

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Free PMC article

Psychopathology in Pediatric Epilepsy: Role of Antiepileptic Drugs

Rochelle Caplan. Front Neurol. .
Free PMC article

Abstract

Children with epilepsy are usually treated with antiepileptic drugs (AEDS). Some AEDs adversely affect behavior in susceptible children. Since psychiatric comorbidity is prevalent in pediatric epilepsy, this paper attempts to disentangle these AED side effects from the psychopathology associated with this illness. It first outlines the clinical and methodological problems involved in determining if AEDs contribute to the behavior and emotional problems of children with epilepsy. It then presents research evidence for and against the role AEDs play in the psychopathology of children with epilepsy, and outlines how future studies might investigate this problem. A brief description of how to clinically separate out AED effects from the complex illness-related and psychosocial factors that contribute to the behavior difficulties of children with epilepsy concludes the paper.

Keywords: antiepileptic drugs; children; epilepsy; psychopathology.

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References

    1. Aldenkamp A. P., Alpherts W. C. J., Sandstedt P., Blennow G., Elmqvist D., Heijbel J., et al. (1998). Antiepileptic drug-related cognitive complaints in seizure-free children with epilepsy before and after drug discontinuation. Epilepsia 39, 1070–107410.1111/j.1528-1157.1998.tb01292.x - DOI - PubMed
    1. Austin J. K., Caplan R. (2007). Behavioral and psychiatric comorbidities in pediatric epilepsy: toward an integrative model. Epilepsia 48, 1639–165110.1111/j.1528-1167.2007.01154.x - DOI - PubMed
    1. Austin J. K., Dunn D. W., Caffrey H. M., Perkins S. M., Harezlak J., Rose D. F. (2002). Recurrent seizures and behavior problems in children with first recognized seizures: a prospective study. Epilepsia 43, 1564–157310.1046/j.1528-1157.2002.26002.x - DOI - PubMed
    1. Austin J. K., Harezlak J., Dunn D. W., Huster G. A., Rose D. F., Ambrosius W. T. (2001). Behavior problems in children before first recognized seizures. Pediatrics 107, 115–12210.1542/peds.107.1.115 - DOI - PubMed
    1. Austin J. K., Perkins S. M., Johnson C. S., Fastenau P. S., Byars A. W., DeGrauw T. J., et al. (2010). Self-esteem and symptoms of depression in children with seizures: relationships with neuropsychological functioning and family variables over time. Epilepsia 51, 2074–208310.1111/j.1528-1167.2010.02575.x - DOI - PubMed

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