[The polymorphism of matrix Gla-protein gene in ischemic atherothrombotic stroke patients]

Fiziol Zh. 2012;58(5):14-21.
[Article in Ukrainian]

Abstract

Matrix Gla protein (MGP) gene allelic polymorphism in 170 patients with ischemic atherothrombotic stroke (IATS) and in 124 healthy people was determined. It was shown that in patients with IATS interrelation of main homozygotes, heterozygotes and minor homozygotes is 61,2, 31,2, 7,6% for T-138 --> C (rs1800802) promoter polymorphism (in control -59.7, 35.6, 4.8%, P = 0.521 by chi2-test); 35.9, 48.8, 15.3% for G(-7) --> A (rs1800801) polymorphism of promotor (in control--43.5, 50.0, 6.5%, P = 0.051); 39.4, 48.8, 11.8% for Thr83 --> Ala (rs4236) polymorphism of 4 exon (in control - 34.7, 53.2, 12.1%, P = 0.701). Significant differences in the frequency of G(-7) --> A polymorphism between patients with IATS and control group were revealed only for women (P = 0.022). The results obtained suggest that the A/A-variant of MGP gene promotor (G(-7) --> A polymorphism) is associated with an increased risk of IATS in female persons in the Ukrainian population.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Brain Ischemia / complications
  • Brain Ischemia / genetics*
  • Calcium-Binding Proteins / genetics*
  • Case-Control Studies
  • European Continental Ancestry Group / genetics*
  • Exons
  • Extracellular Matrix Proteins / genetics*
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Middle Aged
  • Plaque, Atherosclerotic / complications
  • Plaque, Atherosclerotic / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Risk Factors
  • Sex Factors
  • Stroke / complications
  • Stroke / genetics*
  • Ukraine

Substances

  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • matrix Gla protein