[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose]

Ann Dermatol Venereol. 2012 Dec;139(12):824-7. doi: 10.1016/j.annder.2012.06.035. Epub 2012 Sep 5.
[Article in French]

Abstract

Background: Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.

Patients and methods: The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two.

Discussion: This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product.

Publication types

  • Case Reports

MeSH terms

  • Anesthetics, Combined / adverse effects*
  • Child, Preschool
  • Dosage Forms
  • Drug Overdose
  • Female
  • Humans
  • Lidocaine / adverse effects*
  • Lidocaine, Prilocaine Drug Combination
  • Methemoglobinemia / chemically induced*
  • Prilocaine / adverse effects*

Substances

  • Anesthetics, Combined
  • Dosage Forms
  • Lidocaine, Prilocaine Drug Combination
  • Prilocaine
  • Lidocaine