A prospective, multicenter survey on causes of chronic cough in China

doi:10.1378/chest.12-0441

Multicenter Study

. 2013 Mar;143(3):613-620.

doi: 10.1378/chest.12-0441.

A prospective, multicenter survey on causes of chronic cough in China

Kefang Lai¹, Ruchong Chen¹, Jiangtao Lin², Kewu Huang³, Huahao Shen⁴, Lingfei Kong⁵, Xin Zhou⁶, Zhiyang Luo⁷, Lan Yang⁸, Fuqiang Wen⁹, Nanshan Zhong¹⁰

Affiliations

¹ State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong.
² China-Japan Friendship Hospital, Beijing.
³ Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing.
⁴ Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang.
⁵ First Affiliated Hospital, China Medical University, Shenyang, Liaoning.
⁶ Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai.
⁷ First People's Hospital of Foshan, Foshan, Guangdong.
⁸ First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi.
⁹ West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
¹⁰ State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong. Electronic address: Chinananshan@vip.163.com.

PMID: 23238526
DOI: 10.1378/chest.12-0441

Multicenter Study

A prospective, multicenter survey on causes of chronic cough in China

Kefang Lai et al. Chest. 2013 Mar.

. 2013 Mar;143(3):613-620.

doi: 10.1378/chest.12-0441.

Authors

Kefang Lai¹, Ruchong Chen¹, Jiangtao Lin², Kewu Huang³, Huahao Shen⁴, Lingfei Kong⁵, Xin Zhou⁶, Zhiyang Luo⁷, Lan Yang⁸, Fuqiang Wen⁹, Nanshan Zhong¹⁰

Affiliations

¹ State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong.
² China-Japan Friendship Hospital, Beijing.
³ Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing.
⁴ Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang.
⁵ First Affiliated Hospital, China Medical University, Shenyang, Liaoning.
⁶ Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai.
⁷ First People's Hospital of Foshan, Foshan, Guangdong.
⁸ First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi.
⁹ West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
¹⁰ State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong. Electronic address: Chinananshan@vip.163.com.

PMID: 23238526
DOI: 10.1378/chest.12-0441

Abstract

Background: The causes of chronic cough in China and its relations with geography, seasonality, age, and sex are largely uncertain.

Methods: A prospective, multicenter survey was conducted to evaluate patients with chronic cough across five regions in China by using a modified diagnostic algorithm. The effects of geography, seasonality, age, and sex on spectrum of chronic cough were also investigated.

Results: The current study evaluated 704 adult patients, including 315 men (44.7%) and 389 women (55.3%). The causes of chronic cough were determined in 640 subjects (90.9%). Common causes included cough variant asthma (CVA) (32.6%), upper airway cough syndrome (UACS) (18.6%), eosinophilic bronchitis (EB) (17.2%), and atopic cough (AC) (13.2%). Collectively, these four causes accounted for 75.2% to 87.6% across five different regions without significant difference (P > .05), although there was variation on single causes. Gastroesophageal reflux-related cough was identified in 4.6% of causes. Seasonality, sex, and age were not associated with the spectrum of chronic cough (all P > .05).

Conclusion: CVA, UACS, EB, and AC were common causes of chronic cough in China. Geography, seasonality, age, and sex were not associated with the spectrum of chronic cough.

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Comment in

Air pollution and chronic cough in China.
Mao W, Xia W, Chen J. Mao W, et al. Chest. 2013 Jul;144(1):362-363. doi: 10.1378/chest.13-0611. Chest. 2013. PMID: 23880696 No abstract available.
Response.
Lai K, Chen R, Zhong N. Lai K, et al. Chest. 2013 Jul;144(1):363-364. doi: 10.1378/chest.13-0924. Chest. 2013. PMID: 23880697 No abstract available.

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A prospective, multicenter survey on causes of chronic cough in China

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A prospective, multicenter survey on causes of chronic cough in China

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