Effects of phytic acid and exercise on some serum analytes in rats orally exposed to diets supplemented with cadmium

Biol Trace Elem Res. 2013 Mar;151(3):400-5. doi: 10.1007/s12011-012-9572-9. Epub 2012 Dec 14.

Abstract

Cadmium is an environmental pollutant of increasing worldwide concern. It has been reported to be high in the soil where food crops are grown in some parishes of Jamaica. Surprisingly, no adverse effect of cadmium has been reported among the Jamaican population. However, phytic acid has also been shown to be high in some food crops grown in Jamaica. In this study, we evaluated the effects of phytic acid (1 %) and exercise on the metabolism of cadmium (5 mg cadmium/kg body weight) in rats. Five groups of rats were fed as follows: rats fed control diet, control diet supplemented with cadmium and subjected to exercise, control diet supplemented with phytic acid plus cadmium and subjected to exercise, control diet supplemented with cadmium plus phytic acid, and control diet supplemented with cadmium only. The animals were fed for 4 weeks and then sacrificed. Blood samples were collected for some biochemical assays. Percentage weight loss (28.42 %) was greatest in the group that had cadmium supplement only. The group fed control diet supplemented with cadmium only displayed increased liver enzymes and electrolytes except for the significant decrease in bicarbonate compared to other test groups. Similarly, blood urea nitrogen and uric acid were increased in the group fed cadmium supplement only compared to other test groups. Total cholesterol trended downwards in the test groups compared to control. These observations suggest that consumption of diet high in phytic acid with relatively high physical activity may be protective against the adverse effects of cadmium.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood / drug effects
  • Blood / metabolism*
  • Blood Chemical Analysis
  • Cadmium / administration & dosage*
  • Cadmium / adverse effects*
  • Cadmium / metabolism
  • Dietary Supplements*
  • Physical Conditioning, Animal / physiology*
  • Phytic Acid / administration & dosage
  • Phytic Acid / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Cadmium
  • Phytic Acid