Amyloid and its association with default network integrity in Alzheimer's disease

Hum Brain Mapp. 2014 Mar;35(3):779-91. doi: 10.1002/hbm.22213. Epub 2012 Dec 14.


The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.

Keywords: Alzheimer disease; amyloid; default mode network; magnetic resonance imaging; mild cognitive impairment; positron emission tomography; resting-state fMRI.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging* / metabolism
  • Aging* / physiology
  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / physiopathology
  • Amyloid beta-Peptides / metabolism*
  • Aniline Compounds
  • Brain* / metabolism
  • Brain* / physiopathology
  • Cognitive Dysfunction* / metabolism
  • Cognitive Dysfunction* / physiopathology
  • Female
  • Functional Neuroimaging / instrumentation
  • Functional Neuroimaging / methods*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Net* / metabolism
  • Nerve Net* / physiopathology
  • Positron-Emission Tomography / instrumentation
  • Positron-Emission Tomography / methods*
  • Thiazoles


  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid beta-Peptides
  • Aniline Compounds
  • Thiazoles