Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study

Osteoporos Int. 2013 Jul;24(7):2049-59. doi: 10.1007/s00198-012-2233-1. Epub 2012 Dec 13.


This prospective cohort study that comprehensively examined effects of different B vitamins in an Asian population showed an inverse relationship between dietary intake of pyridoxine and hip fracture risk in elderly women. These findings suggest that maintaining sufficient pyridoxine intake may be beneficial in preserving bone health in postmenopausal women.

Introduction: B vitamins have recently been investigated for their possible roles in maintaining bone health. Incidence of osteoporotic hip fracture has been rising in Asia, but epidemiological data on dietary B vitamins and risk of osteoporotic fractures are sparse. We aimed to examine the association between dietary intakes of B vitamins (thiamin, riboflavin, niacin, pyridoxine, folate, and cobalamin) and hip fracture risk among elderly Chinese in Singapore.

Methods: The current study was conducted in the Singapore Chinese Health Study, which is a population-based cohort prospective study that enrolled a total of 63,257 men and women aged 45-74 years between 1993 and 1998. Dietary intakes of B vitamins were derived from a validated food frequency questionnaire and the Singapore Food Composition Database.

Results: After a mean follow-up period of 13.8 years, 1,630 hip fracture incident cases were identified. A statistically significant inverse relationship between dietary pyridoxine intake and hip fracture risk was observed among women (p for trend = 0.002) but not among men. Compared to women in the lowest quartile intake (0.37-0.61 mg/1,000 kcal/day), women in the highest quartile intake (0.78-1.76 mg/1,000 kcal/day) had a 22 % reduction in hip fracture risk (hazard ratio 0.78, 95 % confidence interval 0.66-0.93). Dietary intakes of the other B vitamins of interest were not related to hip fracture risk.

Conclusions: Our findings suggest that maintaining adequate intake of pyridoxine may prevent osteoporotic fractures among elderly women.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asian Continental Ancestry Group / statistics & numerical data
  • China / ethnology
  • Diet / ethnology
  • Diet / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Hip Fractures / ethnology
  • Hip Fractures / prevention & control*
  • Humans
  • Male
  • Middle Aged
  • Osteoporotic Fractures / ethnology
  • Osteoporotic Fractures / prevention & control*
  • Prospective Studies
  • Pyridoxine / administration & dosage
  • Risk Assessment / methods
  • Sex Factors
  • Singapore / epidemiology
  • Vitamin B Complex / administration & dosage*


  • Vitamin B Complex
  • Pyridoxine