Vitamin D and inflammation

Pediatr Nephrol. 2013 Apr;28(4):605-10. doi: 10.1007/s00467-012-2377-4. Epub 2012 Dec 13.


Recent studies have provided evidence for an important role of vitamin D deficiency in the pathogenesis of cardiovascular disease (CVD) in the general population, and of an association with markers of inflammation. Vitamin D deficiency, defined by low serum levels of 25-hydroxyvitamin D, is especially prevalent in patients with chronic kidney disease (CKD). Chronic low-grade inflammation is a hallmark of CKD and has been disclosed as one important factor contributing to the progression of CKD and a high cardiovascular comorbidity. This review highlights clinical and experimental studies that could potentially explain a link between vitamin D and inflammation. Whether correction of vitamin D deficiency has beneficial effects on markers of inflammation and cardiovascular outcome should be investigated by controlled clinical trials.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / metabolism
  • Comorbidity
  • Disease Progression
  • Humans
  • Inflammation / blood
  • Inflammation / epidemiology
  • Inflammation / metabolism*
  • Prognosis
  • Renal Insufficiency, Chronic / blood
  • Renal Insufficiency, Chronic / epidemiology
  • Renal Insufficiency, Chronic / metabolism*
  • Risk Factors
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D / metabolism
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / metabolism*


  • Biomarkers
  • Vitamin D
  • 25-hydroxyvitamin D