Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?

World J Gastroenterol. 2012 Dec 14;18(46):6790-800. doi: 10.3748/wjg.v18.i46.6790.


The purpose of this review was to highlight, in relation to the currently accepted pathophysiology of non-alcoholic fatty liver disease (NAFLD), the known exercise habits of patients with NAFLD and to detail the benefits of lifestyle modification with exercise (and/or physical activity) on parameters of metabolic syndrome. More rigorous, controlled studies of longer duration and defined histopathological end-points comparing exercise alone and other treatment are needed before better, evidence-based physical activity modification guidelines can be established, since several questions remain unanswered.

Keywords: Diet; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Physical activity.

Publication types

  • Review

MeSH terms

  • Diet
  • Exercise*
  • Fatty Liver / physiopathology
  • Fatty Liver / therapy*
  • Hormones / metabolism
  • Humans
  • Insulin Resistance
  • Leptin / metabolism
  • Life Style
  • Lipids
  • Liver / metabolism
  • Metabolic Syndrome / complications
  • Motor Activity
  • Non-alcoholic Fatty Liver Disease
  • Obesity / complications
  • Practice Guidelines as Topic
  • Treatment Outcome


  • Hormones
  • Leptin
  • Lipids