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Review
. 2012 Dec;85(4):447-68.
Epub 2012 Dec 13.

Cytokine Control of Inflammation and Repair in the Pathology of Multiple Sclerosis

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Free PMC article
Review

Cytokine Control of Inflammation and Repair in the Pathology of Multiple Sclerosis

Jane M Rodgers et al. Yale J Biol Med. .
Free PMC article

Abstract

Cytokines are secreted signaling proteins that play an essential role in propagating and regulating immune responses during experimental autoimmune encephalomyelitis (EAE), the mouse model of the neurodegenerative, autoimmune disease multiple sclerosis (MS). EAE pathology is driven by a myelin-specific T cell response that is activated in the periphery and mediates the destruction of myelin upon T cell infiltration into the central nervous system (CNS). Cytokines provide cell signals both in the immune and CNS compartment, but interestingly, some have detrimental effects in the immune compartment while having beneficial effects in the CNS compartment. The complex nature of these signals will be reviewed.

Keywords: cytokines; experimental autoimmune encephalomyelitis; multiple sclerosis; neuroinflammation.

Figures

Figure 1
Figure 1
Diagram of EAE pathology. Stars represent cytokines, octagons represent debris, squares represent chemokines, and yellow circles are endothelial cells.
Figure 2
Figure 2
Diagram of cytokines produced by activated antigen presenting cells during antigen presentation to naïve T cells and the cytokines produced by T helper cells after differentiation. Stars represent cytokines.

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