Comparison of in vitro activity of doripenem, imipenem and meropenem against clinical isolates of Enterobacteriaceae, Pseudomonas and Acinetobacter in Southern Poland

Pol Przegl Chir. 2012 Sep;84(9):449-53. doi: 10.2478/v10035-012-0076-2.

Abstract

In the study we tested drug sensitivity to 3 carbapenems (doripenem, imipenem and meropenem) of Gram-negative clinical isolates from Southern Poland.

Material and methods: 89 strains were examined: 42 from Pseudomonas genus, 16 Acinetobacter baumannii strains and 31 Enterobacteriaceae strains. Etests were used according to the producers instructions, MIC values were interpreted using EUCAST criteria.

Results: Highest in vitro activity against Pseudomonas spp. was shown for doripenem, then meropenem and the lowest for imipenem (MIC values were definitely lower for doripenem; differences were statistically significant); A. baumannii strains showed similar sensitivity to doripenem, meropenem and imipenem (differences non-significant); all Enterobacteriaceae strains showed sensitivity to the tested antimicrobials.

Conclusions: As a conclusion-doripenem, which has high in vitro activity (almost the same as imipenem and meropenem) as well as beneficial pharmacologic properties, may be an alternative solution in the treatment of multiresistant Gram-negative bacteria, especially in patients in severe status who require restrictive antibiotic regimens.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / classification
  • Acinetobacter / drug effects*
  • Acinetobacter baumannii / drug effects
  • Anti-Bacterial Agents / pharmacology
  • Bronchoalveolar Lavage Fluid / microbiology
  • Carbapenems / pharmacology*
  • Doripenem
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects*
  • Humans
  • Imipenem / pharmacology*
  • Meropenem
  • Microbial Sensitivity Tests
  • Poland
  • Pseudomonas / classification
  • Pseudomonas / drug effects*
  • Species Specificity
  • Sputum / microbiology
  • Thienamycins / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Thienamycins
  • Imipenem
  • Doripenem
  • Meropenem