Elevated oral and systemic levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in periodontitis

J Dent Res. 2013 Feb;92(2):161-5. doi: 10.1177/0022034512470691. Epub 2012 Dec 14.


The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study was that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate, by ELISA, the sTREM-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than in the control group, by 3.3-fold and 5.6-fold, respectively. In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full-mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggressive Periodontitis / blood
  • Aggressive Periodontitis / pathology*
  • Biomarkers / analysis
  • Biomarkers / blood
  • Case-Control Studies
  • Chronic Periodontitis / blood
  • Chronic Periodontitis / metabolism*
  • Dental Plaque Index
  • Humans
  • Inflammation Mediators / analysis
  • Inflammation Mediators / blood
  • Interleukin-1beta / analysis
  • Interleukin-1beta / blood
  • Membrane Glycoproteins / analysis*
  • Membrane Glycoproteins / blood
  • Myeloid Cells / metabolism*
  • Periodontal Attachment Loss / blood
  • Periodontal Attachment Loss / pathology
  • Periodontal Index
  • Periodontal Pocket / blood
  • Periodontal Pocket / pathology
  • Periodontium / metabolism
  • Receptors, Immunologic / analysis*
  • Receptors, Immunologic / blood
  • Saliva / chemistry*
  • Smoking
  • Triggering Receptor Expressed on Myeloid Cells-1


  • Biomarkers
  • Inflammation Mediators
  • Interleukin-1beta
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM1 protein, human
  • Triggering Receptor Expressed on Myeloid Cells-1