Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 46 (6), 563-8

[Reversal of Aging and Lifespan Elongation. Current Biomedical Key Publications and the Implications for Geriatrics]

[Article in German]
Affiliations
Review

[Reversal of Aging and Lifespan Elongation. Current Biomedical Key Publications and the Implications for Geriatrics]

[Article in German]
L C Bollheimer et al. Z Gerontol Geriatr.

Abstract

Biological aging means a time-dependent accumulation of changes to which a living organism is being exposed during its lifetime. Biological aging normally concurs with chronological aging the time frame of which is set by an upper limit, the lifespan (in humans approximately 120 years). New findings in experimental biogerontology are challenging both the dogma of irreversibility of biological aging and the preset species-specific limitations of life. The present overview first explains the general principle of rejuvenation and reversal of biological aging with paradigms from stem cell research. Secondly, recent key publications on artificial telomerase elongation and (alleged) lifespan enhancement by sirtuins and resveratrol will be discussed with an emphasis on the implications for (future) geriatric medicine.

Similar articles

See all similar articles

References

    1. Nature. 2003 Sep 11;425(6954):191-6 - PubMed
    1. Genes Dev. 1999 Oct 1;13(19):2570-80 - PubMed
    1. Aging Dis. 2012 Jun;3(3):260-8 - PubMed
    1. Nat Cell Biol. 2011 May;13(5):506-12 - PubMed
    1. Mutat Res. 2012 Feb 1;730(1-2):98-105 - PubMed

LinkOut - more resources

Feedback