Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss

Nutr Res. 2012 Dec;32(12):965-75. doi: 10.1016/j.nutres.2012.09.009. Epub 2012 Oct 24.


In patients diagnosed with osteoporosis, calcium is lost from bones making them weaker and easily susceptible to fractures. Supplementation of calcium is highly recommended for such conditions. However, the source of calcium plays an important role in the amount of calcium that is assimilated into bone. We hypothesize that naturally occurring coral calcium and zeolite may prevent ovariectomy-induced bone loss. We have measured bone loss in ovariectomized mice supplemented with coral calcium and Zeolite. Female C57BL/6 mice were either sham-operated or ovariectomized and fed diets containing coral calcium or zeolite for 6 months. Serum was analyzed for bone biochemical markers and cytokines. Bones were analyzed using dual x-ray absorbtiometry, peripheral quantitative computed tomography, and micro-computed tomography densitometry. In the distal femoral metaphysis, total bone and cortical bone mass was restored and the endocortical surface was significantly decreased in coral calcium and zeolite fed ovariectomized (OVX) mice. Trabecular number and the ratio of bone volume to total volume was higher in OVX mice after coral calcium and zeolite feeding, while trabecular separation decreased in the different treatment OVX groups. Coral calcium protected bone to a lesser extent in the proximal tibia and lumbar vertebrae. Overall, coral calcium and zeolite may protect postmenopausal bone loss.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry
  • Biomarkers / blood
  • Bone Density Conservation Agents / pharmacology
  • Bone Density Conservation Agents / therapeutic use*
  • Bone and Bones / drug effects*
  • Calcium / pharmacology
  • Calcium / therapeutic use*
  • Calcium, Dietary / pharmacology
  • Calcium, Dietary / therapeutic use*
  • Cytokines / blood
  • Dietary Supplements*
  • Disease Models, Animal
  • Female
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Osteoporosis, Postmenopausal / blood
  • Osteoporosis, Postmenopausal / prevention & control*
  • Ovariectomy
  • Trace Elements / pharmacology
  • Trace Elements / therapeutic use
  • Zeolites / pharmacology
  • Zeolites / therapeutic use*


  • Biomarkers
  • Bone Density Conservation Agents
  • Calcium, Dietary
  • Cytokines
  • Trace Elements
  • Zeolites
  • Calcium