Abstract
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis ((1)H and (13)C NMR, (1)H,(1)H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Atlantic Ocean
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Drug Screening Assays, Antitumor
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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HeLa Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Sea Cucumbers / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents
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Glycosides
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Triterpenes
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pseudocnoside A