Effect of plastoquinone derivative 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats

Biochemistry (Mosc). 2012 Dec;77(12):1382-6. doi: 10.1134/S0006297912120061.

Abstract

Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Estradiol / blood*
  • Estrous Cycle / drug effects*
  • Female
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / chemistry
  • Plastoquinone / pharmacology
  • Rats
  • Rats, Wistar

Substances

  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • Estradiol
  • Plastoquinone