Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter

Gene. 2013 Feb 15;515(1):34-41. doi: 10.1016/j.gene.2012.11.058. Epub 2012 Dec 14.


Head-to-head genes with a short distance between their transcription start sites may constitute up to 10% of all genes in the genomes of various species. It was hypothesized that this intergenic space may represent bidirectional promoters which are able to initiate transcription of both genes, but the true bidirectionality was proved only for a few of them. We present experimental evidence that, according to several criteria, a 269 bp region located between the PSENEN and U2AF1L4 human genes is a genuine bidirectional promoter regulating a concerted divergent transcription of these genes. Concerted transcription of PSENEN and U2AF1L4 can be necessary for regulation of T-cell activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid Precursor Protein Secretases / genetics*
  • Amyloid Precursor Protein Secretases / metabolism
  • Cell Line
  • Cloning, Molecular
  • Consensus Sequence
  • Gene Expression Regulation*
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Nucleotide Motifs
  • Organ Specificity / genetics
  • Promoter Regions, Genetic*
  • Protein Subunits / chemistry
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Ribonucleoproteins / chemistry
  • Ribonucleoproteins / genetics*
  • Ribonucleoproteins / metabolism
  • Splicing Factor U2AF
  • Transcription, Genetic


  • Membrane Proteins
  • Nuclear Proteins
  • PSENEN protein, human
  • Protein Subunits
  • Ribonucleoproteins
  • Splicing Factor U2AF
  • U2AF1L4 protein, human
  • Amyloid Precursor Protein Secretases