Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington disease

Arch Clin Neuropsychol. 2013 Mar;28(2):156-68. doi: 10.1093/arclin/acs105. Epub 2012 Dec 16.

Abstract

Executive dysfunction (ED) is a characteristic of Huntington disease (HD), but its severity and progression is less understood in the prodromal phase, e.g., before gross motor abnormalities. We examined planning and problem-solving abilities using the Towers Task in HD mutation-positive individuals without motor symptoms (n = 781) and controls (n = 212). Participants with greater disease progression (determined using mutation size and current age) performed more slowly and with less accuracy on the Towers Task. Performance accuracy was negatively related to striatal volume while both accuracy and working memory were negatively related to frontal white matter volume. Disease progression at baseline was not associated with longitudinal performance over 4 years. Whereas the baseline findings indicate that ED becomes more prevalent with greater disease progression in prodromal HD and can be quantified using the Towers task, the absence of notable longitudinal findings indicates that the Towers Task exhibits limited sensitivity to cognitive decline in this population.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / pathology*
  • Corpus Striatum / pathology
  • Depression / genetics
  • Depression / pathology
  • Depression / psychology*
  • Depressive Disorder / genetics
  • Depressive Disorder / pathology
  • Depressive Disorder / psychology*
  • Disease Progression
  • Executive Function*
  • Female
  • Follow-Up Studies
  • Humans
  • Huntington Disease / genetics
  • Huntington Disease / pathology
  • Huntington Disease / psychology*
  • Longitudinal Studies
  • Male
  • Memory, Short-Term
  • Middle Aged
  • Neuropsychological Tests
  • Problem Solving
  • Prodromal Symptoms*
  • Severity of Illness Index
  • Trinucleotide Repeat Expansion