Immune responses to West Nile virus infection in the central nervous system

Viruses. 2012 Dec 17;4(12):3812-30. doi: 10.3390/v4123812.


West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous system (CNS), the outcome of which can be protection, viral pathogenesis, or immunopathogenesis. We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Central Nervous System / immunology*
  • Central Nervous System / virology*
  • Host-Pathogen Interactions
  • Humans
  • Viral Tropism
  • Virus Internalization
  • West Nile Fever / epidemiology
  • West Nile Fever / veterinary
  • West Nile virus / immunology*
  • West Nile virus / pathogenicity*