2-Pyridone synthesis using 2-(phenylsulfinyl)acetamide

Masaya Fujii; Takuya Nishimura; Takahiro Koshiba; Satoshi Yokoshima; Tohru Fukuyama

doi:10.1021/ol303320c

2-Pyridone synthesis using 2-(phenylsulfinyl)acetamide

Org Lett. 2013 Jan 4;15(1):232-4. doi: 10.1021/ol303320c. Epub 2012 Dec 18.

Authors

Masaya Fujii¹, Takuya Nishimura, Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama

Affiliation

¹ Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Tokyo 113-0033, Japan.

PMID: 23249369
DOI: 10.1021/ol303320c

Abstract

2-Pyridones were prepared by means of an efficient protocol including the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetamides / chemistry*
Combinatorial Chemistry Techniques
Ketones / chemical synthesis
Ketones / chemistry*
Molecular Structure
Pyridones / chemical synthesis*
Pyridones / chemistry
Sulfoxides / chemistry*

Substances

2-(phenylsulfinyl)acetamide
Acetamides
Ketones
Pyridones
Sulfoxides