Few investigations reported the reductive effect of preload consuming on energy intake. The objective of the study was to compare the effects of consuming a mix of low glycaemic index foods such as vegetable salad, yogurt and water before or with meal on anthropometric measures and cardio vascular diseases (CVD) risks. In this randomized controlled clinical trial, 25 men and 35 women were recruited to consume similar amounts of macronutrients within a hypocaloric diet for 3 months. Although subjects in the preload group consumed preload 15 min before the main meal, subjects in the control group consumed them with meal. The results showed that body weight, waist circumference, triglyceride, total cholesterol and systolic blood pressure decreased in more amount in the preload group ( - 7.8 ± 0.5%, - 2.7 ± 0.2%, - 5.7 ± 1.1%, - 3.1 ± 0.53% and - 4.4 ± 0.4%, respectively; p < 0.05 for all). Fasting blood sugar and low density lipoprotein (LDL)-cholesterol decreased significantly only in the preload group. Consuming vegetable salad, yogurt and water as preload leads to greater changes in anthropometric measures and CVD risks.