Proposal for an optimized protocol for intravenous administration of insulin in diabetic patients undergoing (18)F-FDG PET/CT

Nucl Med Commun. 2013 Mar;34(3):271-5. doi: 10.1097/MNM.0b013e32835d1034.


The objective of this study was to evaluate the usefulness and impact of insulin administration before an F-FDG PET/computed tomography (CT) examination in diabetic patients in order to propose an optimized protocol that can reduce blood glucose levels without increasing muscular F-FDG uptake. A total of 130 patients underwent an F-FDG PET/CT. Twenty patients had glucose levels greater than 180 mg/dl and received endovenous insulin before F-FDG injection (group 1); 10 patients had glucose levels greater than 160 mg/dl and lower than 200 mg/dl and received no insulin (group 2); 100 patients were euglycemic (group 3). Biodistribution was adequate in 19 of 20 patients in group 1. Values of standardized uptake value in the gluteal muscle were 0.50±0.18 for group 1, 0.48±0.10 for group 2, and 0.49±0.08 for group 3; no significant differences in muscular F-FDG uptake could be found among the three groups. No adverse events were recorded. In conclusion, our protocol has been demonstrated to be safe and effective, with only a minor impact on glucose biodistribution and apparently without affecting PET accuracy.

MeSH terms

  • Aged
  • Blood Glucose / metabolism
  • Diabetes Mellitus / drug therapy*
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Injections, Intravenous / methods*
  • Insulin / administration & dosage*
  • Male
  • Middle Aged
  • Multimodal Imaging / methods*
  • Muscles / metabolism
  • Positron-Emission Tomography*
  • Radiopharmaceuticals
  • Time Factors
  • Tissue Distribution
  • Tomography, X-Ray Computed*


  • Blood Glucose
  • Insulin
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18