Gene-environment studies and borderline personality disorder: a review

Curr Psychiatry Rep. 2013 Jan;15(1):336. doi: 10.1007/s11920-012-0336-1.

Abstract

We review recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior, aggression and anger, and the borderline personality phenotype itself. Almost all the studies reviewed suffered from a number of methodological and statistical problems, limiting the conclusions that currently can be drawn. The best evidence to date supports a gene-environment correlation (rGE) model for borderline personality traits and a range of adverse life events, indicating that those at risk for BPD are also at increased risk for exposure to environments that may trigger BPD. We provide suggestions regarding future research on GxE interaction and rGE effects in borderline personality.

Publication types

  • Review

MeSH terms

  • Aggression / psychology
  • Borderline Personality Disorder / genetics*
  • Borderline Personality Disorder / psychology
  • Emotions
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease
  • Humans
  • Impulsive Behavior / genetics
  • Impulsive Behavior / psychology
  • Phenotype
  • Risk Factors
  • Suicidal Ideation