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, 2 (4), 237-48

Airway Reflux, Cough and Respiratory Disease

Affiliations

Airway Reflux, Cough and Respiratory Disease

Ian D Molyneux et al. Ther Adv Chronic Dis.

Abstract

It is increasingly accepted that the effects of gastro-oesophageal reflux are not limited to the gastrointestinal tract. The adjacent respiratory structures are also at risk from material ejected from the proximal oesophagus as a result of the failure of anatomical and physiological barriers. There is evidence of the influence of reflux on several respiratory and otorhinological conditions and although in many cases the precise mechanism has yet to be elucidated, the association alone opens potential novel avenues of therapy to clinicians struggling to treat patients with apparently intractable respiratory complaints. This review provides a description of the airway reflux syndrome, its effects on the lung and current and future therapeutic options.

Keywords: airways reflux; cough; respiratory disease; therapy.

Conflict of interest statement

The authors declare no conflict of interest in preparing this manuscript.

Figures

Figure 1.
Figure 1.
Proposed mechanism of reflux to the airway causing respiratory symptoms. LOS, lower oesophageal sphincter; TLOSR, transient lower oesophageal sphincter relaxation; TRPA1, transient receptor potential (ankyrin receptor); TRPV1, transient receptor potential (vanilloid sensitive).

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