Children's Oncology Group's 2013 blueprint for research: Hodgkin lymphoma

Pediatr Blood Cancer. 2013 Jun;60(6):972-8. doi: 10.1002/pbc.24423. Epub 2012 Dec 19.


In childhood Hodgkin lymphoma, estimated 5 years survival rates exceed 90%. Long-term survival continues to decline from delayed toxicities. Key findings from recent Children's Oncology Group trials include: (1) Radiotherapy selection may be based on early chemotherapy response assessed by both FDG-PET and CT imaging, (2) A new prognostic factor score stratifies patients into risk categories; and (3) novel retrieval regimens were identified. A phase I/II trial is investigating Brentuximab vedotin (Bv) with gemcitabine in relapsed patients. A phase 3 trial will modify conventional chemotherapy and radiotherapy approaches through the addition of Bv, while incorporating translational biology to identify molecular targets.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Chemoradiotherapy
  • Child
  • Clinical Trials as Topic*
  • Hodgkin Disease / therapy*
  • Humans
  • Prognosis
  • Radiotherapy
  • Research
  • Risk Factors