Movement disorders in mitochondrial myopathies. A study of nine cases with two autopsy studies

Mov Disord. 1990;5(2):109-17. doi: 10.1002/mds.870050204.


Of 85 consecutive patients with mitochondrial myopathy, 29 had clinically significant central nervous system involvement. Nine of these had movement disorders that included dystonia, chorea, parkinsonism, and myoclonus. Autopsy studies of one patient with ataxia, dementia, and parkinsonism followed by dystonia showed the features of olivopontocerebellar atrophy with additional degenerative changes in the basal ganglia. Postmortem in a further case with myoclonus, deafness, muscle weakness, retinopathy, and ataxia showed symmetrical mineralisation of the striatopallidodentatal system.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mitochondria, Muscle / metabolism
  • Mitochondria, Muscle / pathology*
  • Movement Disorders / etiology*
  • Movement Disorders / pathology
  • Movement Disorders / physiopathology
  • Muscular Diseases / complications*