Tissue-specific neutrophil recruitment into the lung, liver, and kidney

J Innate Immun. 2013;5(4):348-57. doi: 10.1159/000345943. Epub 2012 Dec 21.


The recruitment of immune cells is crucial for the development of inflammatory processes. The classical recruitment cascade of neutrophils into inflamed tissues is well understood and consists of capturing, rolling, slow rolling, arrest, postadhesion strengthening, crawling, and transmigration. While this commonly agreed paradigm might be applicable to most peripheral tissues, recruitment mechanisms may substantially vary in different organs such as the lung, liver, and kidney. These organs are highly specialized tissues with unique cell populations and structural organization, which enables them to fulfill their individual functions. The published research over the last decade has shed some light on organ-specific mechanisms of neutrophil recruitment and helped to generate a deeper understanding of the specific recruitment mechanisms involved in this process. The aim of this review is to highlight current concepts of tissue-specific differences and similarities of neutrophil recruitment into the lung, liver, and kidney.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Humans
  • Kidney / immunology*
  • Leukocyte Rolling / immunology
  • Liver / immunology*
  • Lung / immunology*
  • Neutrophils / immunology*
  • Organ Specificity
  • Transendothelial and Transepithelial Migration