Protein homeostasis: live long, won't prosper

Nat Rev Mol Cell Biol. 2013 Jan;14(1):55-61. doi: 10.1038/nrm3496.


Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime. This diverse group of long-lived proteins might be particularly prone to accumulation of damage and thus have a crucial role in the functional deterioration of key regulatory processes during ageing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cellular Senescence*
  • Homeostasis
  • Humans
  • Protein Biosynthesis
  • Proteins / metabolism*
  • Proteome / metabolism*


  • Proteins
  • Proteome