Comparative analysis of bat genomes provides insight into the evolution of flight and immunity

Science. 2013 Jan 25;339(6118):456-60. doi: 10.1126/science.1230835. Epub 2012 Dec 20.


Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Evolution*
  • Chiroptera / genetics*
  • Chiroptera / immunology
  • Chiroptera / physiology
  • DNA Damage / genetics
  • DNA Repair / genetics
  • Echolocation
  • Evolution, Molecular
  • Flight, Animal*
  • Genetic Speciation
  • Genome*
  • Hibernation / genetics
  • High-Throughput Nucleotide Sequencing
  • Immunity, Innate / genetics*
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Reactive Oxygen Species / metabolism
  • Selection, Genetic
  • Sequence Analysis, DNA*
  • Species Specificity


  • Reactive Oxygen Species

Associated data

  • GEO/GSE39933