Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? A controlled study of 70 cases

Andrology. 2013 Jan;1(1):120-8. doi: 10.1111/j.2047-2927.2012.00007.x. Epub 2012 Sep 7.


The medical treatment is indicated in the development stage of Peyronie's disease (PD) for at least 1 year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in PD treatment, whereas in the scientific literature this topic is much discussed. A total of 70 patients (age:26-69 years, mean: 54.1 ± 9.71) diagnosed with PD were enrolled in a conservative treatment. In addition to medical histories and physical examinations all patients underwent the following tests: International Index of Erectile Function (IIEF) questionnaire, penile ultrasound and photographic documentation, pain evaluation by a conventional 10-point pain scale Visual analogue pain scale (VAS). All 70 patients were divided into two different treatment groups: A and B, with different combinations of drugs: A = vitamin E + verapamil (injection + iontophoresis) + blueberries + propolis + topical diclofenac; B = verapamil (injection + iontophoresis) + blueberries + propolis + topical diclofenac. All patients were treated for 6 months after which they underwent the same follow-up tests as performed prior to the treatment. Intergroup analysis revealed statistically significant differences: in the vitamin E group the effective plaque size reduction was -50.2% whereas in the control group the reduction was -35.8% (p = 0.027). In group A the improvement of curvature occurred in 96.6% of the cases whereas in the control group B this occurred in 48.4% (p = 0.0001), moreover, the mean curvature decrease was respectively -12.25° and -6.73° (p = 0.01). IIEF score was significantly improved in group A patients with comorbidities and erectile dysfunction (p = 0.025). Increase in plaque size occurred only in the control group (17.1%) (p = 0.032). We can affirm that vitamin E can help to prevent the progression of PD. This study strongly supports the recommendation that the best approach for treating PD is multimodal therapy.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Blueberry Plants
  • Calcium Channel Blockers / administration & dosage
  • Diclofenac / administration & dosage
  • Dietary Supplements*
  • Disease Progression
  • Drug Therapy, Combination
  • Fruit
  • Humans
  • Injections, Intralesional
  • Iontophoresis
  • Male
  • Middle Aged
  • Penile Induration / diagnosis
  • Penile Induration / drug therapy*
  • Propolis / therapeutic use
  • Rome
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome
  • Verapamil / administration & dosage
  • Vitamin E / therapeutic use*
  • Vitamins / therapeutic use*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Calcium Channel Blockers
  • Vitamins
  • Vitamin E
  • Diclofenac
  • Propolis
  • Verapamil